查看: 152|回复: 0

文献求助[Curr Drug Res Rev .]

[复制链接]
发表于 2021-3-1 12:40:14 | 显示全部楼层 |阅读模式
DOI号:
10.2174/2589977512666200220122650
发帖时间:
2021-3-1 12:39
文献网址:
Curr Drug Res Rev .
备注:
Background: Resistance to glucocorticoid (GC)-induced apoptosis in Acute Lymphoblastic Leukemia (ALL), is considered one of the major prognostic factors for the disease. Prednisolone is a corticosteroid and one of the most important agents in the treatment of acute lymphoblastic leukemia. The mechanics of GC resistance are largely unknown and intense ongoing research focuses on this topic.
Gene Expression and Resistance to Glucocorticoid-Induced Apoptosis in Acute Lymphoblastic Leukemia: A Brief Review and Update
Aim: The aim of the present study is to review some aspects of GC resistance in ALL, and in particular of Prednisolone, with emphasis on previous and present knowledge on gene expression and signaling pathways playing a role in the phenomenon.
Methods: An electronic literature search was conducted by the authors from 1994 to June 2019. Original articles and systematic reviews selected, and the titles and abstracts of papers screened to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved.
Results: Identification of gene targets responsible for glucocorticoid resistance may allow discovery of drugs, which in combination with glucocorticoids may increase the effectiveness of anti-leukemia therapies. The inherent plasticity of clinically evolving cancer justifies approaches to characterize and prevent undesirable activation of early oncogenic pathways.
Conclusion: Study of the pattern of intracellular signal pathway activation by anticancer drugs can lead to development of efficient treatment strategies by reducing detrimental secondary effects.

Keywords: Glucocorticoids; RelA; acute lymphoblastic leukemia; apoptosis; gene expression; glucocorticoid-induced apoptosis resistance; prednisolone.

回复

使用道具 举报

您需要登录后才可以回帖 登录 | 立即注册

本版积分规则

开通VIP|小黑屋|手机版|版权归属及声明|谷粉学术论坛  

Copyright © 2008-2020 谷粉学术论坛(http://bbs.99lb.net) 版权所有 Reserved.

Powered by 学术论坛 X3.1  信息产业部备案/经营许可证编号 蜀ICP备4234235号QQ

快速回复 返回顶部 返回列表